The correlation between vascular cell adhesion molecule-1 and gastric carcinoma / 中国现代普通外科进展

ABSTRACT

To detect the expression of VCAM 1 (vascular cell adhesion molecule 1)in gastric cancer,its adjacent tissues, gastric ulcer and normal tissues, and the correlation of expression of VCAM 1 with tumor growth,metastasis, pathological parameters.Methods: Specimens from 41 gastric cancer patients(cancer, adjacent cancer and normal tissue),8 peptic ulcer,10 normal peoples were stained, image analysis with the methods of immunohistochemistry.The relation of the data collected with clinic and pathology of gastric cancer was studied. The correlation of VCAM 1 expression and pathological characteristics of gastric cancer were studied.Results: VCAM 1 was expressed not only in vascular endothelial cells, but also in most gastric cancer cells, thirty one out of forty one cancer had the expression of VCAM 1,adjacent cancer(2cm) had 5 positive VCAM 1 and adjacent cancer(5cm) had 4 positive VCAM 1(P