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Analysis of infiltirating T cell clonotypes in joints for murine RA / 中国免疫学杂志
Chinese Journal of Immunology ; (12)1985.
Artículo en Chino | WPRIM | ID: wpr-674972
ABSTRACT

Objective:

To study the relationship between the T cell clonotypes and RA,carried out the analysis of infiltrating T cell clonotypes in foot of a murine model of spontaneous RA

Methods:

RT PCR and SSCP were used for this study

Results:

The identical rate of V?2 and V?8 2 clonotypes of T cells in different foot joints is 68 1 percent and 59 2 percent separately The assay of RT PCR/SSCP showed there were identical V?2 and V?8 2 clonotypes in four foot joints of all SKG mice(100%) DNA sequencing showed that the same DNA bands in samples from different joints by SSCP were the same T cell clonotypes The assay of T cell transformation suggested that clonotypes of T cells showed up in joints is related to morbid formation of RA

Conclusion:

This investigation indicated that T cells of V?2 and V?8 2 TCR types probably play an important role in SKG murine RA

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Journal of Immunology Año: 1985 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Journal of Immunology Año: 1985 Tipo del documento: Artículo