Pharmacokinetics of intraperitoneal chemotherapy for ovarian cancer / 中国癌症杂志

ABSTRACT

Purpose:To study the pharmacokinetic characteristics and systemic exposure of intraperitoneal chemotherapy drugs for ovarian cancer. Methods:Ten ovarian cancer patients received intraperitoneal chemotherapy with 5 FU 750mg/m 2 and DDP 60mgm 2 a week later after operating at Shanghai Cancer Hospital. The blood samples were extracted at 0.5, 1, 2, 6, 24 hour after infusion and then the concentration of drugs in the samples were analyzed by HPLC and the atomic absorption spectrum methods. Results:The curve of concentration via time of two drugs could be described well by a one compartment model with first order absorption. The pharmacokinetic parameters were 5 FU Ke = 0.45?0.18 /h, Ka = 7.59?4.63 /h, T(peak) = 0.87?0.30 h, C(max) = 2.46 ? 1.12 ?g/ml, AUC = 8.38?4.71 ?g?h/ml, Vd = 316?69.4 ml/kg; DDP Ke = 0.014?0.01 /h, Ka = 1.31?1.03 /h, T(peak) = 4.72?2.81 h, C(max) = 0.85?0.28 ?g/ml, AUC = 85.6?55.7 ?g?h/ml, Vd = 60.3?32.6 ml/kg. The AUC 0～24h of 5 FU was 8.4 ?g?h/ml. The AUC 0～24h of DDP was 14.4 ?g?h/ml. Conclusions:The systemic exposure of 5 FU in intraperitoneal chemotherapy was not lower than in intravenous injection on the pharmcokinetics, and that of the DDP was lower.