A study on the changing tendency of IgG to coronavirus associated severe acute respiratory syndrome / 中国免疫学杂志

ABSTRACT

Objective:To explore the changing tendency of IgG to coronavirus associated severe acute respiratory syndrome(SARS).Methods:Between 1 and 153 days after the onset of symptoms, the antibody IgG to SARS associated coronavirus were detected in 534 patients with SRAS by ELISA. 216 randomly selected people without SARS contact history and SARS symptoms were contrasted.Results:The positive rates of IgG between SARS patients and control group respectivel were 58 1%,0 5%.There is a statistical significance(P=0 000).Among SARS patients, the positive rates of IgG in 1～10 days,11～30 days,31～60 days,61～90 days,91～120 days,above 120 days and after the onset of symptoms respectively were 18 8%(3/16 cases),63 8%(37/58 cases),55 6%(30/54 cases),51 4%(71/138 cases),62 1%(159/256 cases),83 3%(10/12 cases).Conclusion:There are low positive rates of IgG in SARS patients in the first 10 days after onset of symptoms, and abruptly ascending positive rates of IgG in 11～30 days.The positive rates of IgG remains the high levels during 4th and 5th months.Further observation is essential to elucidating the duration of IgG.