Palliative treatment of bone pain related to prostatic cancer metastasis with bisphosphonates / 中华泌尿外科杂志

ABSTRACT

Objective To investigate the role of bisphosphates in the treatment of advanced prostatic cancer patients complaining of bone pain due to metastasis. Methods The clinical data of 40 cases of prostatic cancer with skeletal complications were retrospectively analyzed.Based on the post castrating conditions and therapeutic approaches,the 40 cases were divided into 3 groups.12 cases in Group A received oral androgen blockade plus bonefos,a type of bisphosphonates,following orchectomy;17 cases in Group B received oral androgen blockade following orchectomy;11 cases in Group C who had hormone refractory prostatic cancer receives oral bonefos.The severity of bone pain and quality of life before treatment and 2, 4 weeks after treatment were compared among the 3 groups using visual analogue score (VAS) and Karnofsky score of quality of life. Results Compared with the state of pre treatment,the patients got bone pain relief after 4 weeks’ treatment (VAS7.3 vs 2.5 in Group A;7.6 vs 2.3 in Group B;7.9 vs 4.6 in Group C,respectively, P