The study of HLA-A,DRB1 allele polymorphism in cirrhosis patients due to hepatitis B / 中国免疫学杂志

ABSTRACT

Objective:In order to find a possible relationship between the polymorphism of HLA A,DRB1 allele and susceptibility to cirrhosis due to hepatitis B.Methods:HLA A,DRB1 allele polymorphism in 61 patients with cirrhosis due to hepatitis B were analyzed by DNA chip,146 healthy subjects as control group were also tested.Results:The most frequent alleles were HLA A02,11,24 for HLA A locus and HLA DRB112,09,04 for HLA DRB1 locus in control group respectively,the significantly increased frequencies of HLA A02(43 4% vs 29 1%,OR1 87,P=0 005,95% CI1 21 2 89)与HLA DRB107(13 9% vs 5 1%,OR3 00,P=0 002,95% CI1 48 6 07)、HLA DRB108(16 4% vs 6 8%,OR2 67,P=0 003,95% CI1 40 5 08)、HLA DRB111(12 3% vs 5 8%,OR2 27,P=0 025,95% CI1 11 4 64) were found in cirrhosis patients due to hepatitis B compared to the control group,the homozygotes of HLA A02 showed a tendency to increase in cirrhosis patients,but failed to reach statistical significance.Conclusion:HLA A02 and HLA DRB107、08、11 may be susceptibility genes for cirrhosis due to hepatitis B. [