A Serine12Stop mutation in PB1-F2 of the 2009 pandemic (H1N1) influenza A: a possible reason for its enhanced transmission and pathogenicity to humans
Journal of Veterinary Science
;
: 349-351, 2009.
Artículo
en Inglés
| WPRIM
| ID: wpr-67598
ABSTRACT
As the scientific community scrambles to define the ancestry and lineages of the eight segments of new pandemic H1N1 strain, we looked for unique genetic events in this virus's genome to explain the newly found enhanced virulence and transmissibility among humans. Genome annotations of this virus identified a stop mutation replacing serine at codon 12 (S12Stop) of the PB1-F2 protein, a virulence factor in influenza A viruses. Here, we discuss the significance of this finding and how it may contribute to host specialization, explaining the virtual absence of the H1N1 influenza A virus strain in pig populations. This finding is expected to lead to a better understanding of the transmission and pathogenesis of the 2009 pandemic strain.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Proteínas Virales
/
Virulencia
/
Datos de Secuencia Molecular
/
Regulación Viral de la Expresión Génica
/
Secuencia de Aminoácidos
/
Gripe Humana
/
Subtipo H1N1 del Virus de la Influenza A
/
Interacciones Huésped-Patógeno
/
Mutación
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Journal of Veterinary Science
Año:
2009
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS