Estrogen receptor gene polymorphisms and risk of women's malignant tumor related to estrogen / 肿瘤研究与临床

ABSTRACT

Estrogen receptors(ER)has two subtype alpha and beta.It is a kind of glycoprotein which can bond to estrogen(E).They distribute all kinds of organs and tissues,especially in procreation organs and breast tissue.Study showed that estrogen receptor gene polymorphisms had been associated with the risk of carcinogenesis of endometrial cancer,ovarian cancer and breast cancer.We reviewed the molecule structure, function,gene polymorphisms of ER,and the relationship with endometrial cancer,ovarian cancer and breast cancer.