Relationship between adrenomedullin and diabetic tubulointerstitial injury / 中华内分泌代谢杂志

ABSTRACT

Forty-two patients with type 2 diabetes mellitus (DM) were refered to 3 groupstype 2 DM without diabetic nephropathy (DN),type 2 DM with DN in the initial stage and type 2 DM with DN in the clinical stage.Ten healthy subjects were served as control group.Plasma adrenomedullin (ADM),urinary?_1- microglobulin (MG) and?_2-MG were detected.The results showed that the level of plasma ADM rose gradually with the development of DN and was positively correlated with markers of tubulointerstiial injury such as urinary?_1- MG and?_2-MG (both P