EFFECT OF TOTAL ARALOSIDES ON PROSTAGLANDINS AND CYCLIC NUCLEOTIDE / 中国药理学通报

ABSTRACT

The total aralosides extracted from Aralia elata (Miq) Seem. were studied in mice ( 50 mg/kg/d for 7 d ) to investigate the pharmacological mechanisms on the molecular level.The results showed that aralosides can obviously stimulate the production of PGE2、PGF2, and cAMP but reduce the cGMP level and nave no effect on histamine release.It is suggested that the changes in the level of cyclic nucleotide might be due to the alternations of PGs, which is now been suspected as the "Second Messenger" . These findings could explain in part the pharmacological activities of aralosides on the molecular level.