ANTIARRHYTHMIC EFFECT OF TOTAL FLAVONES OF HIPPOPHASE RHAMNOIDES IN THE ISOLATED HEART / 中国药理学通报

ABSTRACT

In the isolated perfused rat heart, TFH counteracted significantly the arrhythmias caused by perfusing with a solution without oxygen; increased ventricular fibrillation threshold markedly and showed a good dose-effective relation; prolonged the P-R period of electrocardiogram and decreased the heart rate and fell the amplitude of cardiac contraction markedly; and counteracted significantly the decrease of the heart rate and the amplitude of cardiac contraction caused by perfusing with a solution without oxygen. In the isolated guinea pig left atrium, TFH prolonged the function refractory period slightly. In the isolated guinea pig right atrium, TFH increased the accumulated dose of aconitine inducing arrhythmias.