An experimental study on permeability of basic fibroblast growth factor through placental barrier in rats / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12)2000.
Artículo
en Chino
| WPRIM
| ID: wpr-677437
ABSTRACT
Objective:
To investigate if bFGF can penetrate placental barrier.Methods:
Sixteen day pregnant Wistar rats were selected. bFGF labeled with 125 I was injected peritoneally into the rats. The radioactivity of bFGF in different organs were determined in 30 min.Results:
(1) 125 I bFGF was detected in the brain, heart, liver,lung and spleen. (2)With the same dose of 125 I bFGF, the concentration of it in the brain was at lowest level of all other organs.(3) In the range of safe dose, the permeability of bFGF through placental barrier was increased obviously.Conclusion:
bFGF may penetrate placental barrier into rat's brain, which makes possible for the therapeutic intervention of bFGF in feotus. [
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Academic Journal of Second Military Medical University
Año:
2000
Tipo del documento:
Artículo
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