Clinicopathological characteristics of extremely young Korean multiple myeloma patients: therapeutic implications
The Korean Journal of Internal Medicine
;
: 722-730, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-67784
ABSTRACT
BACKGROUND/AIMS:
Although multiple myeloma (MM) is typically a disease of the elderly, a certain subset of extremely young patients exists. It is necessary to establish clinicopathological characteristics for this population.METHODS:
We reviewed the medical records of MM patients whose age was 40 years or younger at diagnosis.RESULTS:
A total of 32 patients were analyzed (male to female ratio 1913, median age 37 years). According to International Staging System, 29%, 48%, and 16% were in stage I, II, and III, respectively. Light chain myeloma accounted for 30%. Clinically significant anemia, hypercalcemia, azotemia, and hypoalbuminemia were present in 29%, 28%, 13%, and 28%, respectively. Three or more lytic bone lesions were detected in 45% of the patients, whereas 13% had no lytic bone lesions. Regarding treatment, 79% of patients received autologous hematopoietic stem cell transplantation. After a median follow-up duration of 64 months, the 1-, 3-, and 5-year overall survival (OS) rates were 84%, 62%, and 54%, respectively. The median OS was 61 months for the entire cohort.CONCLUSIONS:
In our study, MM patients aged 40 years or younger at diagnosis showed no superior survival compared to those of the moderately elderly patients based on historical data.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Registros Médicos
/
Estudios de Cohortes
/
Estudios de Seguimiento
/
Resultado del Tratamiento
/
Trasplante de Células Madre Hematopoyéticas
/
Hipoalbuminemia
/
Diagnóstico
/
Azotemia
/
Hipercalcemia
/
Anemia
Tipo de estudio:
Estudio diagnóstico
/
Estudio de etiología
/
Estudio de incidencia
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Anciano
/
Femenino
/
Humanos
Idioma:
Inglés
Revista:
The Korean Journal of Internal Medicine
Año:
2017
Tipo del documento:
Artículo
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