~1H MR spectroscopy of C6 glioma after tumor necrosis factor-?therapy / 中华放射学杂志

ABSTRACT

Objective To observe the therapeutic effect of tumor necrosis factor ?(TNF ?) on C6 glioma using 1?H MR spectroscopy, and to evaluate the practical value of 1?H MR spectroscopy in observing therapeutic effect Methods C6 cell mixed with low boiling point argarous were inoculated in caudate nuclear in 33 rats by using sterotatic method By using high magnetic field spectrometer, high resolution 1?H MR spectroscopy was carried at a 3 day interval until 15 days after treatment with TNF ? The relative choline containing compound (Cho),N acetyl aspartate (NAA),creatine (Cr), Cho/Cr,NAA /Cr,and NAA/Cho were analyzed with statistic method Results The Cho decreased obviously 3 days after TNF ? treatment( P