Improved effect of melatonin on learning and memory in mice with repeated cerebral ischemia and reperfusion and its mechanism / 中国临床药理学与治疗学

ABSTRACT

AIM: To study the protective effect and mechanism of melatonin on learning and memory in mice with repeated cerebral ischemia and reperfusion and its mechanism. METHODS: The models of repeated cerebral ischemia reperfusion were established in mice. The function of learning and memory was tested by the electric mare method, and the concentrations of MDA and NO were measured by colorimetric method and nitric reduction method in brain tissue. RESULTS: MT could obviously improve the function of learning and memory of model mice, inhibit cerebral dropsy, and lower the content of MDA and NO in cerebral tissue. CONCLUSION: MT shows significantly protective effect against repeated ischemia reperfusion injury in mice, and the mechanism might be related to inhibit the rise of MDA and NO in brain tissue.