HELICOBACTER PYLORI INFECTION IS NOT RELATED TO hMLH1 AND APC MUTATION AND PROMOTER METHYLATION IN GASTRIC CANCER / 解放军医学杂志

ABSTRACT

0 05). APC mutation was correlated with intestinal type of gastric cancer ( P 0 05). APC mutation was detected in all MSI Low or MSS, while no mutation was found in MSI H. Conclusion hMLH1 mutation and promoter methylation are involved in MSI pathway and APC mutation is involved in LOH pathway in gastric cancer. H pylori infection is not related to hMLH1, APC mutation and promoter methylation in gastric cancer.