Expression levels of E-cd and Ki67 in non-small cell lung carcinoma and the clinical significance / 第三军医大学学报

ABSTRACT

Objective To investigate the expression levels of E cadherin (E cd) and proliferation related antigen Ki67 and their roles in the mechanism of invasion and metastasis of non small cell lung carcinoma(NSCLC). Methods The expression levels of E cd and Ki67 antigen were detected by immunohistochemistry. Results The positive rates of E cd in the cases of Ⅲ Ⅳ stage and Ⅰ Ⅱ stage were 33 3% and 65 7%, respectively, but those of Ki67 were 96 3% and 68 6%. The expression levels of E cd and Ki67 in cases with metastasis were significantly different from those in cases without metastasis. Conclusion The expression levels of E cd and Ki67 are closely associated with invasion and metastasis of NSCLC. The expression level of E cd is negatively correlated with that of Ki67 in NSCLC.