Negative feedback regulation of TGF-?/Smad signaling pathway by Smad7 in renal fibrosis / 第二军医大学学报

ABSTRACT

TGF ? plays a crucial role in the renal fibrosis and Smads mediate the intracellular signal transduction of TGF ?.Overexpression of Smad7,which can mediate TGF ? by the feedback action,is able to change the physiopathology equilibrium between the R Smads response and the I Smads inhibition to the fibrosis induced by TGF ?.It may help to understand the mechanism of renal fibrosis and Smads TGF ? signaling transduction, and it may also provide a new approach to the renal fibrosis.