Reinduction of Hyponatremia by Vasopressin to Prevent Osmotic Demyelinating Syndrome / 대한신장학회잡지

ABSTRACT

Rapid correction of chronic hyponatremia can be associated with osmotic demyelinating syndrome leading to irreversible brain injury. Therefore, the primary efforts must be focused on maintaining appropriate correction rate (<10-15 mEq/L/24hr). But overcorrection may occur unpredictably in various circumstances. However, several reports showed that rapid relowering of the serum sodium level prevents osmotic demyelinating syndrome and reduces neurological injury. We report two cases of overcorrected chronic hyponatremia. After overshooting, we considered the risk of osmotic demyelinating syndrome and injected vasopressin to patients. The serum sodium concentrations were relowered immediately with no neurological deficit. There was no significant side effect of vasopressin.