Oxygen-induced brain BOLD-fMRI signal change / 第二军医大学学报

ABSTRACT

Objective:To observe the signal changes of blood-oxygen-level-dependent functional MRI(BOLD-fMRI)in brain tissue after inhalation of oxygen.Methods:Fifteen volunteers,9 males and 6 females,were included in the present experiment.The fMRI was conducted using 1.5T Singna Double-gradient Super Conducting Magnetic Resonance Imaging system (GE Inc).Bold-fMRI scanning was conducted using GRE-EPI sequence and data analysis was done using SPM2 software. Meanwhile,the BOLD-fMRI T_2 signal changes after 15 s and 6 min inhalation of pure oxygen were observed and compared with those after inhaling normal air.Results:No obvious activation of BOLD-fMRI was observed in the whole brain after inhaling normal air.Fifteen seconds after inhaling pure oxygen,the signal changes in the whole brain mainly manifested as the signal decrease in the gray matter,with average signal change being(-0.041?0.31)% in the gray matter and about(0.056?0.26)% in the white matter;the changes were significantly different from those of the normal air group(P