Role of adiponectin and its receptors in anti-atherosclerotic effects of pioglitazone on ApoE knocked out mice / 北京大学学报(医学版)
Journal of Peking University(Health Sciences)
;
(6)2004.
Artículo
en Chino
| WPRIM
| ID: wpr-680508
ABSTRACT
Objective:
To study the effects of pioglitazone on atherosclerosis on ApoE-/-mice,and to investigate the roles of adiponectin and its receptors.Methods:
ApoE-/-mice were fed with high-fat chow for the induction of atherosclerosis and were divided into three subgroupsplacebo(n=10),low-dose[10 mg/(kg?d),n=10] pioglitazone therapy,and high-dose[20 mg/(kg?d),n=10] pioglitazone therapy.C57BL/6J wild type mice(n=9) were used as control.Aortic atherosclerosis and intima-media thickness(intima-media thickness,IMT) of abdominal aorta were monitored,and plasma adiponectin was also measured.Expression levels of the adiponectin receptor 1(AdipoR1)and adiponectin receptor 2(AdipoR2) in vessels were analyzed(RT-PCR).Results:
(1) Aortic atherosclerotic lesions were observed in ApoE-/-mice but not in wild type mice.Interestingly,these lesions were significantly prevented by high-dose pioglitazone therapy.Compared with wild type mice,ApoE-/-mice had increased IMT of abdominal aorta [(0.290?0.063 vs 0.178?0.012) cm,P
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Ensayo Clínico Controlado
Idioma:
Chino
Revista:
Journal of Peking University(Health Sciences)
Año:
2004
Tipo del documento:
Artículo
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