Effect of geniposide on lithogenesis of cholesterol calculus in gall ducts of syria golden hamsters / 中草药

ABSTRACT

Object To study the effect of geniposide in the prophylaxis of cholesterol calculus formation in gall ducts of Syria Golden hamster Methods Experimental hamster models with cholesterol calculus was prepared by feeding lithogenous diet with high content of fat and protein for 30 d with simultaneous administration of geniposide at doses of 50 and 100 mg/kg/d ig or ursodeoxycholic acid as positive control at the dose of 80 mg/kg/d After the last dosage, the hamsters were sacrificed and their gallstone formation rate were determined by examining the smear of gallbladder content and their lithogenous index (LI) were calculated from the assay of lipoid substances in bile such as cholesterol (Ch), bile acids (Bs) and phospholipid (Pl) Results The gallstone formation rate in the blank model group, geniposide 50 and 100 mg/kg were 100%, 40% (P