Pharmacokinetical study on Sini Decoction / 中成药
Chinese Traditional Patent Medicine
;
(12)1992.
Artículo
en Chino
| WPRIM
| ID: wpr-681794
ABSTRACT
Objective:
To study the correlation of pharmacokinetics(PK) and pharmacodynamics(PD) of Sini Decoction (SND) (Radix Aconiti Praeparata, Rhizoma Zingiberis, Radix Glycyrrhizae, etc.) and reveal the compatibility of SND.Methods:
Using the drug serums from the same source, we determined the plasma concentration in vivo in dog and the pharmacological effects at the same time inspected by the contents of aconitine type alkaloids and nitric oxide (NO).Results:
The data of PK and PD can be both described by one compartment open model with first order absorption in vivo in dog and the parameters of two methods are similar. The results show that the effective fraction of SND gives a prompt and lasting effect in accordance with characteristic function of SND.Conclusion:
A good correlation exists in SND of the parameters between pharmacokinetics and pharmacodynamics.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio pronóstico
Idioma:
Chino
Revista:
Chinese Traditional Patent Medicine
Año:
1992
Tipo del documento:
Artículo
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