Effect of mild hypothermia on blood pressure when used for the treatment of experimental brain infarction in rats / 中华物理医学与康复杂志

ABSTRACT

Objective To investigate the changes of blood pressure in rats with experimental brain infarction caused by use of mild hypothermia. Methods One hundred and twenty Sprague Dawley rats were used and divided randomly and equally into a control group and an experiment group. In all of the rats, the middle cerebral artery occlusion (MCAO) was made to cause the experimental brain infarction, and reperfused 2 hours later. Three hours after MCAO, the rats in the experiment group were placed in the 4℃ with the rectal temperature controlled at 34? 1.0℃ , while those in the control group in the room temperature. The heart rate, breath, blood pressure, oxygen saturation and rectal temperature were monitored. The rats were sacrificed 24 hours after MCAO and the infarction volume were observed. Results After MCAO, the blood pressure was significantly increased as compared with that prior to MCAO ( P 0.05) . Hypothermia significantly reduced the blood pressure after being used for more than 3 hours ( P