Study on pharmacodynamics effect of Fuyuanbunao Granules on ATPase activities and lipid peroxidation in Alzheimer' disease mouse / 中成药

ABSTRACT

AIM: To study effects of Fuyuanbunao Granules (Radix Ginseng Rubra, Fructus Crataegi, Radix Astragali, Herba Epimedii, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Rhizoma Acori Tatarinowii) on ATPase activities, MDA level in mouse brain, SOD activities in mouse blood and the quotient of brain. METHODS: On the mouse model of Alzheimer' disease toxified with AlCl 3, the effects of Fuyuanbunao Granules on Na + K + ATPase, Mg 2+ ATPase activities and MDA level in mouse brain, SOD activities in mouse blood were evaluated with spectroscopic analysis, and the weight of brain was measured with analytical balance. RESULTS: Compared with Alzheimer'disease model team, Fuyuanbunao Granules enhance the activities of Na +、K + ATPase, Mg 2+ ATPase, decease MDA level in the mouse brain and enhance the activities of SOD in blood. It also increases the weight of brain. CONCLUSION: It indicates that enhancing the activity of ATPase and deceasing peroxide level may be one of the mechanism for Fuyuanbunao Granules to prevent and cure Alzheimer' disease.