Expression of human leucocyte antigen G on haman placenta and its gene polymorphism in relation to intrahepatic cholestasis of pregnancy / 中华妇产科杂志

ABSTRACT

0.05).Conclusions The reduced expression of HLA-G on placenta in ICP patients may alter the maternal-fetal immune response and thus be involved in the pathogenesis of this disorder. Dexamethasone can upregulate the expression of HLA-G on placenta.The 14 bp deletion polymorphism in exon 8 of HLA-G gene might not have a significant influence on the development of ICP.