Protective effects of NMT on MCAO induced-focal brain ischemia-reperfusion injury in rats / 医学研究生学报

ABSTRACT

Objectives: To study the protective effects of Nao Mai Tong(NMT) on middle cerebral artery occlusion(MCAO) induced focal brain ischemia reperfusion injury in rats. Methods: After rats were respectively given NMT 1 g/kg, 3 g/kg, 9 g/kg ig everyday for 1 week, the effects of NMT on the histological changes and behavior disorder caused by focal brain ischemia reperfusion which was made by occlusion of middle cerebral artery were investigated. The gasping time after the cutting of the head in ischemia reperfusion rat was recorded. The contents of ATP and LA were determined by radioimmunoassay. Results: NMT significantly reduced the extent of behavior disorder, descended the rate of cerebral infarction area, and improved histological injury of brain tissues. The grasping time after head cutting was prolonged. It was found that the level of ATP was increased and LA was decreased markedly. Conclusions: NMT shows a significant protective effect on histological, behavior and energy metabolic consequences of MCAO induced focal brain ischemia reperfusion injury.