Review of the role of Dll4-Notch signaling pathway in angiogenesis / 基础医学与临床

ABSTRACT

Angiogenesis is regulated by complex interactions of multiple activators and inhibitors.Vascular endothelial growth factor(VEGF)and Notch signaling pathway are involved in such process.Recent studies have demonstrated that Notch signaling pathway plays a key role in the embryonic development and tumour angiogenesis,and identified the role of Dll4-Notch signaling during vascular development and the mechanism of the vascular defects which result from reduction of Notch signaling,thus Dll4-Notch became regarded as novel and important drug targets for disrupting tumour angiogenesis.This review emphasizes on introduction of the constitution of Notch signaling pathway,the role of Dll4-Notch in angiogenesis and the significance of Dll4-Notch for tumour therapy.