Telmisartan Prevent Oxidative Injuries in Endothelial Cells Induced by High Glucose / 中华高血压杂志
Chinese Journal of Hypertension
;
(12)2007.
Artículo
en Chino
| WPRIM
| ID: wpr-685817
ABSTRACT
Objective To investigate the effect of telmisartan on the oxidative stress induced by high glucose in human umbilical vein endothelial cell (HUVEC) in vitro.Methods HUVEC were cocultured with telmisartan (1?10~(-6) mol/L) and various concentration of glucose(5,30 mmol/L) for 0,12,24,36,48 h respectively. The level of MDA in the supernatants of cultured endothelial cells was measured by thiobarbituric acid test,SOD was determined by xanthine oxidase test.The protein expression of peroxisome proliferator activated receptors ? (PPAR-?) in HUVEC 24 h was assessed by Western blot after treatments.Results High glucose significantly increase the levels of MDA (before1.2?0.06 vs after1.6?0.1 mmol/mL,P
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Hypertension
Año:
2007
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS