Expression of Smad 2 and 3 on the Lesions of Leprosy / 대한피부과학회지
Korean Journal of Dermatology
;
: 304-308, 2006.
Artículo
en Coreano
| WPRIM
| ID: wpr-68604
ABSTRACT
BACKGROUND:
Leprosy is an infectious disease with two polar forms, tuberculoid leprosy (TT) and lepromatous leprosy (LL), that are characterized by strong cell-mediated immunity (CMI) and CMI anergy, respectively. Transforming growth factor-beta (TGF-beta) is a family of growth factors involved in essential physiological processes, including development, differentiation, tissue repair, cell growth control and inflammation. Cellular signaling by TGF-beta family members is initiated by the assembly of specific cell surface receptors that activate transcription factors of the Smad family. Deregulation of the TGF-beta-Smad signaling pathway has been implicated in developmental disorders and several human diseases. Recently, ELISA & immunohistochemistry revealed high expression of TGF-beta isoforms in LL.OBJECTIVE:
The purpose of this study was to investigate TGF-beta-Smad signaling in various forms of leprosy.METHODS:
We investigated the involvement of TGF-beta by immunohistochemical staining for Smad 2 and 3 in skin biopsies from six patients of BL and four patients of TT.RESULTS:
The inflammatory cells, keratinocytes and fibroblasts in BL showed strong positivity for both Smad 2 and 3, whereas those in TT showed little positivity.CONCLUSION:
The high expression of Smad 2/3 in BL could represent high expression of TGF-beta, which possibly contributes to local CMI anergy and other clinical characteristic features of leprosy.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Piel
/
Factores de Transcripción
/
Biopsia
/
Ensayo de Inmunoadsorción Enzimática
/
Inmunohistoquímica
/
Lepra Lepromatosa
/
Lepra Tuberculoide
/
Queratinocitos
/
Enfermedades Transmisibles
/
Factor de Crecimiento Transformador beta
Límite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Dermatology
Año:
2006
Tipo del documento:
Artículo
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