Effects of Hibiscus sabdariffa Linn.fruit extracts on α-glucosidase enzyme, glucose diffusion and wound healing activities
Asian Pacific Journal of Tropical Biomedicine
;
(12): 466-472, 2017.
Artículo
en Chino
| WPRIM
| ID: wpr-686596
ABSTRACT
Objective:
To provide in vitro evidence for antidiabetic activity through potential inhibition of α-glucosidase enzyme,glucose diffusion and enhancement in the wound healing using methanolic extract and fractions from Hibiscus sabdariffa Linn.fruit.Methods:
The inhibitory action of methanolic extract and fractions of such fruit on α-glucosidase enzyme and glucose movement through in vitro assay assessment was reported.Their activities on wound healing were tested using the scratch assay.Results:
Ethyl acetate fraction at 50 mg/mL concentration exhibited significant α-glucosidase inhibition (95.79 mg/mL) with P < 0.05.At the same concentration,the methanolic extract as well as other fractions revealed lower α-glucosidase inhibition and higher glucose diffusion retardation across the dialysis tube than the control.Ethyl acetate and butanol fractions displayed notably higher glucose diffusion inhibitory activity of 5.21 mmol/L and 5.2 mmol/L,respectively as compared to methanolic extract and n-hexane fraction of 6.58 mmol/L and 6.49 mmol/L,respectively.Conversely,compared to other fractions the methanolic extract and ethyl acetate fraction manifested proliferative effect at the incubation time of 6 h during the wound healing study.Conclusions:
It is established that methanolic extract and fractions from H.sabdariffa Linu.fruit can inhibit the α-glucosidase enzyme and glucose movement as well as influence the wound healing activity positively.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Asian Pacific Journal of Tropical Biomedicine
Año:
2017
Tipo del documento:
Artículo
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