Progress in genetic research on primary pulmonary hypertension / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 600-603, 2018.
Article
en Zh
| WPRIM
| ID: wpr-688183
Biblioteca responsable:
WPRO
ABSTRACT
Primary pulmonary hypertension (PPH) consisting of hereditary pulmonary arterial hypertension and idiopathic pulmonary arterial hypertension is an obstructive pulmonary hypertension caused by primary pulmonary artery hyperplasia. Both environmental and genetic factors are involved in the pathogenesis of PPH. Genes associated with TGF-β signaling pathway including BMPR2, ALK1, ENG, SMAD8 and other genes including NFU1, CAV1, KCNK3 and TopBPl have been associated with PPH. In this review, the function and mechanism of the above genes in the pathogenesis PPH are summarized.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Año:
2018
Tipo del documento:
Article