Your browser doesn't support javascript.
loading
Research Progress on the Role of Pyroptosis in the Pathogenesis of Myelodysplastic Syndrome -Review / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 937-941, 2018.
Artículo en Chino | WPRIM | ID: wpr-689549
ABSTRACT
Pyroptosis is a novel type of programmed cell death, which is closely related with the pathogenesis of myelodysplastic syndromes (MDS). The recent studies showed that all of S100A9/TLR4, S100A9/CD33 and Nox/ROS signaling pathways can activate oxygen-sensitivity NLRP3 inflammasome and then induce the pyroptosis of hematopoeitic stem cells (HSC) / hematopeitic pregenitor cells (HPC), resulting in ineffective hematopoiesis in patients with MDS. Further studies on the role and molecular mechanism of pyroptosis in the pathogenesis of MDS will provide the potential opportunity for the diagnosis and treatment of MDS. Here, the recent advances in the role and mechnism of pyroptosis in the pathogenesis of MDS are reviewed.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Síndromes Mielodisplásicos / Transducción de Señal / Inflamasomas / Piroptosis / Hematopoyesis Tipo de estudio: Estudio de etiología Límite: Humanos Idioma: Chino Revista: Journal of Experimental Hematology Año: 2018 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Síndromes Mielodisplásicos / Transducción de Señal / Inflamasomas / Piroptosis / Hematopoyesis Tipo de estudio: Estudio de etiología Límite: Humanos Idioma: Chino Revista: Journal of Experimental Hematology Año: 2018 Tipo del documento: Artículo