Research Progress on the Role of Pyroptosis in the Pathogenesis of Myelodysplastic Syndrome -Review / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 937-941, 2018.
Article
en Zh
| WPRIM
| ID: wpr-689549
Biblioteca responsable:
WPRO
ABSTRACT
Pyroptosis is a novel type of programmed cell death, which is closely related with the pathogenesis of myelodysplastic syndromes (MDS). The recent studies showed that all of S100A9/TLR4, S100A9/CD33 and Nox/ROS signaling pathways can activate oxygen-sensitivity NLRP3 inflammasome and then induce the pyroptosis of hematopoeitic stem cells (HSC) / hematopeitic pregenitor cells (HPC), resulting in ineffective hematopoiesis in patients with MDS. Further studies on the role and molecular mechanism of pyroptosis in the pathogenesis of MDS will provide the potential opportunity for the diagnosis and treatment of MDS. Here, the recent advances in the role and mechnism of pyroptosis in the pathogenesis of MDS are reviewed.
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Síndromes Mielodisplásicos
/
Transducción de Señal
/
Inflamasomas
/
Piroptosis
/
Hematopoyesis
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Año:
2018
Tipo del documento:
Article