Expression of IL-17 and MMP-13 in Bone Marrow Biopsy of Pafsents with Multiple Myeloma and Its Clicnical Significomce / 中国实验血液学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the expression of interleukin-17（IL-17）and matrix metalloproteinase-13 （MMP-13）in bone marrow biopsy of patients with multiple myeloma（MM）and its clicnical siginficonce.</p><p><b>METHODS</b>The expressions of IL-17 and MMP-13 in bone marrow biopsy of 47 patients with MM and 10 normal persons as controls were determined with immunohistochemical method.</p><p><b>RESULTS</b>The mean optical density of IL-17 and MMP-13 in MM group was significantly higher than that in control group（P<0.01）. The mean optical density of IL-17 and MMP-13 positive expression in osteolytic lesions of MM group was significantly higher than that in patients without osteolytic lesions. The expression of NF-κB-p65 in MM group was significantly higher than that in control group（P<0.05）; however the IL-17 level positively correlated with MMP-13 expression level（r=0.514） in MM group. The levels of IL-17 and MMP-13 in patients with ineffective treatment were very significantly higher than those in patients with effective trealment（P<0.01）.</p><p><b>CONCLUSION</b>The expression of IL-17 and MMP-13 in MM patients is significantly higher than that in the control group，and the expression of IL-17 and MMP-13 closely relate with MBD，which may be involved in the pathogenesis of MBD through NF-κB pathway，while the IL-17 and MMP-13 may serve as potential indicator for evaluation of therapeutic efficacy.</p>