MMP Inhibitor Ilomastat Improves Survival of Mice Exposed to γ-Irradiation / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 467-472, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-690633
ABSTRACT
There is still a need for better protection against or mitigation of the effects of ionizing radiation following conventional radiotherapy or accidental exposure. The objective of our current study was to investigate the possible roles of matrix metalloproteinase inhibitor, ilomastat, in the protection of mice from total body radiation (TBI), and the underlying protective mechanisms. Ilomastat treatment increased the survival of mice after TBI. Ilomastat pretreatment promoted recovery of hematological and immunological cells in mice after 6 Gy γ-ray TBI. Our findings suggest the potential of ilomastat to protect against or mitigate the effects of radiation.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Efectos de la Radiación
/
Traumatismos Experimentales por Radiación
/
Protectores contra Radiación
/
Bazo
/
Sangre
/
Células Sanguíneas
/
Análisis de Supervivencia
/
Irradiación Corporal Total
/
Usos Terapéuticos
/
Relación Dosis-Respuesta a Droga
Límite:
Animales
Idioma:
Inglés
Revista:
Biomedical and Environmental Sciences
Año:
2018
Tipo del documento:
Artículo
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