Your browser doesn't support javascript.
loading
Advances in the Molecular Diagnosis and Therapy of Relapsed/Refractory Diffuse Large B-cell Lymphoma -Review / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 603-608, 2018.
Artículo en Chino | WPRIM | ID: wpr-690942
ABSTRACT
Diffuse large B-cell lymphoma (DLBCL) is biologically aggressive and most common pathological type of non-Hodgkin's lymphoma (NHL), and about one-third of these patients are refractory or relapsed ultimately. Based on the molecular heterogeneity, DLBCL can be divided into 3 main molecular subtypes germinal center B-cell like (GCB), activated B-cell like (ABC) and primary mediastinal B-cell lymphoma (PMBL). Arising from B cells at distinct stages of differentiation, these subtypes are also diverse in mechanisms of oncogenic activation. So targeting specific oncogene addictions within the DLBCL subtypes offers a more-precise approach to therapy in comparison with the traditional chemotherapies, undoubtedly bringing a bright hope for the treatment of relapsed/refractory DLBCL. In this article, the advances in diagnosis and therapy of GCB-DLBCL, ABC-DLBCL and PMBL relapsed/refractory diffuse large B-cell lymphoma are summarized.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Linfocitos B / Protocolos de Quimioterapia Combinada Antineoplásica / Linfoma de Células B Grandes Difuso / Neoplasias del Mediastino Tipo de estudio: Estudio diagnóstico Límite: Humanos Idioma: Chino Revista: Journal of Experimental Hematology Año: 2018 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Linfocitos B / Protocolos de Quimioterapia Combinada Antineoplásica / Linfoma de Células B Grandes Difuso / Neoplasias del Mediastino Tipo de estudio: Estudio diagnóstico Límite: Humanos Idioma: Chino Revista: Journal of Experimental Hematology Año: 2018 Tipo del documento: Artículo