Expression of CXCL10 ,CXCR3 and T cell subsets in peripheral blood and effect of compound Chinese medicine on it in patients with advanced vitiligo / 重庆医学
Chongqing Medicine
;
(36): 164-166, 2018.
Artículo
en Chino
| WPRIM
| ID: wpr-691759
ABSTRACT
Objective To detect the expression levels of peripheral blood CXCL10 and its receptor CXCR3 and T cell subsets in of the patients with advanced vitiligo and the influence of compound Chinese medicine on it.Methods Flow cytometry was used to detect the cellular proportions of peripheral blood T cell subsets,ELISA was employed to quantify serum CXCL10 and CXCR3 expression levels before and after treatment.Results After 1 month of taking Chinese medicine,the proportions of CD3+ CD4+ cells and CD3+ CD8+ cells were increased compared before treatment(P<0.05).The expression level of peripheral serum CXCL10 before treatment was significantly increased compare with the healthy control group(P<0.01),and the CXCL10 level after treatment was decreased significantly compared with that before treatment(P<0.05).The expression level of peripheral serum CXCR3 was significantly increased compared with the healthy control group(P<0.05),while which after treatment was still significantly higher than that in the healthy control group(P<0.05).Conclusion CXCL10,CXCR3 and T cell subsets proportion may be involved in the pathogenesis of vitiligo.The compound Chinese medicine used in this study plays the curative effect possibly by regulating T cell subsets and expression levels of CXCL10 and CXCR3.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chongqing Medicine
Año:
2018
Tipo del documento:
Artículo
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