Study on effect of rhubarb water extract and ethanol extract on blood fat in experimental hyperlipidemia mice / 重庆医学

ABSTRACT

Objective To investigate the effect of single use and 11 combination use of rhubarb water extract and ethanol extract on blood fat in experimental hyperlipidemia mice.Methods Kunming male mice weighing 20-25 g were selected,given dif-ferent methods of gavage and divided into the control group(Con),model group(Mod),test 1 group(Rhe1,water extract),test 2 group(Rhe2,ethanol extract),test 3 group(water extract and ethanol extract 11 compatibility group).The levels of serum total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C)in each group were detected on 28 d after experiment.Results The TG and LDL-C levels in the test 1 group were lower than those in the model group(P<0.05),the HDL-C level was higher than that in the model group(P<0.05);the levels of TC,TG and LDL-C in the test 2 group were lower than those in the model group,the HDL-C level was higher than that in the model group(P>0.05);compared with the test 1 group,the levels of TG and LDL-C in the test 2 group were decreased(P<0.05);compared with the test 2 group and test 1 group,the levels of TC,TG and LDL-C in the test 3 group were decreased and the HDL-C level was in-creased(P<0.05).Conclusion Using ethanol for extracting rhubarb has better effect for reducing blood fat.