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Study on the mechanism of miRNA-129-5p in epithelial-mesenchymal transition of biliary atresia mouse / 重庆医学
Chongqing Medicine ; (36): 1723-1726, 2018.
Artículo en Chino | WPRIM | ID: wpr-692008
ABSTRACT
Objective To investigate the mechanism of miRNA-129-5p in epithelial-mesenchymal transition (EMT)of biliary atresia.Methods Constructed bile duct epithelial EMT cell model (the experimental group) induced by TGF-β1,detected the expressions of EMT related markers and miRNA-129-5p.While miRNA-129-5p precursor was transfected,the expressions of EMT related markers and extracellular matrix were contrasted between the original and the renovated biliary epithelial cells.Results In the experimental group,extrahepatic bile duct showedEMT,the expression of miRNA-129-5p was decreased (P<0.05),overexpression of miRNA-129-5p could inhibit the progression of EMT (P<0.05).Conclusion miRNA-129-5p may relate to EMT by regulating the expression of TGF-β1.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chongqing Medicine Año: 2018 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chongqing Medicine Año: 2018 Tipo del documento: Artículo