Effect of the continuous positive airway pressure on refractory hypertension in patients with obstructive sleep apnea hypopnea syndrome / 中国耳鼻咽喉头颈外科

ABSTRACT

OBJECTIVE To investigate the effect of continuous positive airway pressure(CPAP) on blood pressure in patients with obstructive sleep apnea hypopnea syndrome(OSAHS) and refractory hypertension.METHODS Fifty five OSAHS patients with refractory hypertension were treated with CPAP.Ambulatory blood pressure monitoring was performed to the patients before and 6 months after the treatment.RESULTS After treatment,the blood pressure of all the patients decreased at different degrees.The mean of 24 h systolic blood pressure(SBP) and 24 h diastolic blood pressure(DBP) decreased from (136.4±2.8)mmHg and (85.6± 1.7)mmHg to (126.9± 1.0)mmHg and (76.8± 1.3)mmHg,the differences were statistically significant(P＜0.05).The mean decrease of 24 h SBP and DBP were (9.6 ± 3.0)mmHg and (8.7± 2.0)mmHg.The decrease value of 24 h SBP and DBP were concerned with apnea and hypopnea index.The numbers of antihypertensive drugs decreased in 31 patients.CONCLUSION After CPAP treatment,the blood pressure of the patients with OSAHS and refractory hypertension dropped significantly,and the varieties of antihypertensive drugs taken in these patients were reduced significantly.