Advance in miRNAs in viral myocarditis / 国际儿科学杂志

ABSTRACT

Micro RNAs (microRNAs,miRNAs) are non-coding,endogenous,small RNA molecules that regulate gene expression.MiRNAs are involved in the development of heart and blood vessels.The abnormal expression of miRNAs is associated with atherosclerosis,coronary heart disease,heart failure and hypertension.In recent years,a series of advances have been made in the study of coronary heart disease,hypertension,arrhythmia,heart failure,cardiovascular remodeling,heart development,and the functional control of myocardial cells,endothelial cells,smooth muscle cells.Viral myocarditis (VMC)is a common cardiovascular disease.The pathogenesis of VMC is not fully elucidated.VMC is mainly caused by coxsackie virus B3 (CVB3)infection.The research confirms that miRNAs are closely related to CVB3.MiRNAs are involved in the pathogenesis of VMC,which play an important role in the development of VMC.The research of miRNAs in the role in viral myocarditis will contribute to further understanding for the pathogenesis of myocarditis and highlighting new direction for the treatment of VMC.This paper reviews the relationship between miRNAs and CVB3,and the role of miRNAs in the pathogenesis of VMC.