The interaction between monoaminergic system and hypothalamic-pituitary-adrenal axis / 国际儿科学杂志

ABSTRACT

Attention deficit hyperactivity disorder (ADHD) is one of the common neurodevelopmental disorders in childhood characterized by inattention,hyperactivity,impulsivity,cognitive impairment and learning difficulties and has a negative effect on children.The specific pathogenesis of ADHD is not fully clear.Recent studies have found that there are interactions between monoaminergic system and hypothalamic-pituitary-adrenal axis,in which the machanism is associated with transcription factors,such as Spl、KLF11、R1.This article reviews the characteristics of the monoaminergic system and hypothalamic-pituitary-adrenal axis in attention deficit hyperactivity disorder,and the machanism with transcription factors.