Progress in human rhinovirus infection in children / 国际儿科学杂志

ABSTRACT

Human rhinovirus(hRV)has been recognized as an important pathogen causing respiratory tract infections in children.HRV belongs to the small RNA virus family.The viral capsid consists of four viral capsid proteins,VP1,VP2,VP3 and VP4.VP1 is the major antigen that producing protective antibodies.There are more than 120 serotypes of hRV.HRV is transmitted mainly through the respiratory tract,and infants are susceptible to hRV.HRV binds intercellular adhesion molecule-1 (ICAM-1)of airway epithelial cells,replicating in airway epithelial cells and local lymph tissues,causing inflammatory reaction and releasing inflammatory mediators,which can cause respiratory symptoms.HRV can not only cause respiratory tract infection,but also has close relationship with the onset of asthma in children.Among the various detection methods,RT-PCR has been proved to be rapid and sensitive,and widely used in the detection of hRV.Anti-hRV drugs are still in development.