Detection and clinical value of serum myocardial enzyme and immune function in children with bronchial asthma / 国际检验医学杂志

ABSTRACT

Objective To investigate the changes of serum myocardial enzyme and immune function in chil-dren with bronchial asthma,and to evaluate the clinical value of level detection.Methods 100 children with bronchial asthma were divided into acute attack group and remission group,50 cases in each group,50 healthy children were selected as control group;the level of serum myocardial enzyme(AST,LDH,CK,CK-MB)and Tlymphocyte subsets(CD3+,CD4+,CD8+,CD4+/CD8+)were compared between the 3 groups,and to ana-lyze the correlation between levels and disease.Results The levels of AST,LDH,CK,CK-MB,CD4+and CD4+/CD8+in the children with asthma exacerbation and remission were significantly higher than those in the control group,and levels of acute attack group was significantly higher than the remission group,the difference was statistically significant(P<0.05).The level of CD8+in the acute attack group and remission group was significantly lower than that in the control group,and the level of the acute attack group was signif-icantly lower than that of the control group,the difference was statistically significant(P<0.05).Severity of bronchial asthma was significant positive correlation with AST,LDH,CK,CK-MB,CD4+and CD4+/CD8+(P<0.05),the severity of bronchial asthma was negatively correlated with the level of CD 8+(P<0.05).Conclu-sion There were different degrees of myocardial damage and abnormal immune function in children with bronchial asthma.With the aggravation of the disease,the level of myocardial enzyme and immune function of children with asthma were more significantly abnormal.