The significance of serum IL-18,IL-22 and IL-23 levels in rheumatoid arthritis / 国际检验医学杂志

ABSTRACT

Objective To study the significance of serum interleukin(IL)-18,IL-22 and IL-23 levels in rheumatoid arthritis.Methods 40 patients of rheumatoid arthritis w ho received therapy from December 2014 to December 2016 in our hospital were selected,and 40 cases of healthy people in our hospital for the same pe-riod were selected as a control group,the expressions of serum IL-18,IL-22 and IL-23 were compared between the two groups;The relationship between the serum IL-18,IL-22,IL-23 and the severity of rheumatoid arthri-tis,before and after treatment and clinical indicators were analyzed.Results The serum IL-18[(741.82 ± 45.60)pg/mL],IL-22[(62.34 ± 3.72)pg/mL]and IL-23[(141.73 ± 18.31)pg/mL]in rheumatoid arthritis group were higher than that of control group[(231.28 ± 26.71),(37.26 ± 3.91),(48.28 ± 5.70)pg/mL],and the difference has statistical significance(P<0.05);the serum IL-18,IL-22 and IL-23 in highly active group rheumatoid arthritis patients were significantly higher than that of moderate active group and stable/mild ac-tive group,serum IL-18,IL-22 and IL-23 in the moderate active group were significantly higher than that of stable/mild active group,and the difference has statistical significance(P<0.05);after treatment,the serum levels of IL-18,IL-22 and IL-23 in patients with rheumatoid arthritis were significantly lower than those before treatment,and the difference has statistical significance(P< 0.05);the results of correlation analysis show that there was a positive correlation between the serum IL-18 and joint tenderness index,joint swelling index, C reactive protein and bone destruction score(P<0.05),and there was a positive correlation between the ser-um IL-22,IL-23 and VAS score,the time of morning stiffness,joint pain index,swelling index,platelet count,C reaction protein and done destruction score(P<0.05).Conclusion The serum IL-18,IL-22,and IL-23 are closely related to the severity of rheumatoid arthritis,which can increase with the aggravation of disease,and it also helps to assess the effectiveness of disease treatment,application value is high.