Serum TNF-α,IL-1β and IL-6 expression levels and significance of children with severe pneumococcal infection / 国际检验医学杂志

ABSTRACT

Objective To explore serum tumor necrosis factor-α(TNF-α),interleukin 1β(IL-1β),interleu-kin 6(IL-6)expression levels and clinical significance of children with severe pneumococcal infection.Methods 37 cases of children with severe Streptococcus pneumococcal infection(severe infection group)and 36 cases with normal Streptococcus pneumoniae infection(normal infection group)treated in our hospital from January 2016 to January 2017 were enrolled as the study objects,and 37 cases of healthy children were enrolled as the control group in the same period.The levels of immunoglobulin IgA,IgM,IgG and the levels of TNF-,IL-1 and IL-6 in the serum of all children were detected.Results CD3+,CD4+,CD4+/CD8+,IgA and IgG levels in the severe infection group,the normal infection group were significantly lower than those of the control group (P<0.05).Serum TNF-α,IL-1β and IL-6 levels in the severe infection group were significantly higher than those in the normal infection group,and the normal infection group were higher than the control group(P<0.05).Serum TNF-α,IL-1β and IL-6 levels in acute period of the severe infection group were significantly higher than those in recovery period of the same group and same period of the normal infection group,and the acute period were higher than in recovery period of the same group(P<0.05).IL-1β level in recovery period of the severe infection group were significantly higher than that in recovery period of the normal infection group and the control group(P<0.05).Conclusion Children with severe pneumococcal infection have im-mune dysfunction,and serum TNF-α,IL-1β,IL-6 levels significantly increased.These data suggest that the three can be used as a reference marker for assessing the severity of severe pneumococcal infections.