Clinical significance of four plasma levels in patients with early diabetic nephropathy / 国际检验医学杂志

ABSTRACT

Objective To investigate the significance of plasma retinol binding protein (RBP),Cystatin C (CysC),soluble intercellular adhesion factor 1 (sICAM 1) and urinary microalbumin (u-MALB) in the detec-tion of early diabetic nephropathy.Methods 40 patients with diabetic nephropathy received from May 2015 to May 2016 at the Capital Medical University Desheng Teaching and Research Center were selected as the ob-servation group and 40 healthy subjects were selected as the control group.Both groups were tested by using immunoassay and biochemical analyzer.Then RBP,CysC,sICAM-1 and u-MALB results in two groups were compared.The sensitivity and specificity of individual and combined detection of related indexes were analyzed by ROC curve.Results The levels of RBP,CysC,sICAM-1 and u-MALB in the observation group [(1.36 ± 0.03)mg/mL,(1.43 ± 0.10)mg/L,(208.72 ± 30.34)ng/mL,(42.39 ± 3.32)mg/L] were higher than those in the control group [(0.33 ± 0.01)mg/mL,(0.14 ± 0.01)mg/L,(85.39 ± 16.85)ng/mL,(10.31 ± 2.20)mg/L],and the difference was statistically significant (P< 0.05).The positive rate of combined detection was higher than single detection of RBP,CysC,sICAM-1 and u-MALB.Conclusion RBP,CysC,sICAM-1 and u-MALB are effective indicators to reflect the patient′s renal injury.The combined detection could effectively improve the positive rate of diagnosis of diabetic nephropathy and monitoring the levels of RBP,CysC,sICAM-1 and u-M ALB level in diabetic nephropathy patients is important for the diagnosis of the onset and the devel-opment of early kidney injury,and the treatment and the progression of the disease.