Value of serum 25 hydroxy vitamin D ,homocysteine and apolipoprotein B/A1 in patients with essential hypertension / 国际检验医学杂志

ABSTRACT

Objective To investigate the value of serum 25 hydroxy vitamin D [25(OH)D] ,homocysteine (Hcy) and apolipoprotein B/A1 in patients with essential hypertension.Methods Totally 191 cases of essen-tial hypertension admitted in the hospital from May 2016 to May 2017 were selected as observation group ,and were divided into hypertension grade 1 group (54 cases) ,hypertension grade 2 group (78 cases) ,hypertension grade 3 group (59 cases) in accordance with the classification of hypertension.54 healthy people who under-went healthy assessment during the same period were selected as the control group.The changes of serum 25 (OH) D ,Hcy and apolipoprotein B/A1 ,and the sensitivity and the specificity of combined detection of 25 (OH)D ,Hcy and apolipoprotein B/A1 were compared.Results The serum 25 (OH) D level in the observa-tion group was lower than that in the control group ,while the levels of Hcy and apolipoprotein B/A1 were higher than those in the control group ,and the differences were statistically significant (P＜0.05).The level of serum 25 (OH) (OH) D in hypertension grade 3 group was lower than those in hypertension grade 2 group and hypertension grade 1 group ,but the levels of Hcy and apolipoprotein B/A1 were higher than those in hy-pertension grade 2 group and hypertension grade 1 group ,and the differencs were statistically significant (P＜0.05) ;the level of serum 25 (OH) D in hypertension grade 2 group was lower than that in hypertension grade 1 group ,but the levels of Hcy and apolipoprotein B/A1 were higher than those in hypertension grade 1 group , and the difference was statistically significant (P＜0.05).The sensitivity and the specificity of combined de- tection of 25 (OH) D ,Hcy and apolipoprotein B/A1 were higher than those of single detection of 25 (OH) D , Hcy and apolipoprotein B/A1.Conclusion Serum 25 (OH) D level decreased in patients with essential hyper-tension ,while Hcy and apolipoprotein B/A1 levels increased ,and the combined detection of 25(OH)D ,Hcy and apolipoprotein B/A1 had high sensitivity and specificity in diagnosis.