Correlations of platelet-to-lymphocyte ratio with large atherosclerotic stroke and its severity / 国际脑血管病杂志

ABSTRACT

Objective To investigate the correlations of peripheral blood platelet-to-lymphocyte ratio (PLR) with large atherosclerotic (LAA) stroke and its severity.Methods Inpatients with acute ischemic stroke admitted to hospital were enrolkel retrospectively.They were divided into LAA and non-LAA (including cardioembolism,small vessel occlusion,other undetermined etiology,and undetermined etiology) according to the TOAST classification.LAA was further divided into a mild stroke group (score ＜8) and a moderate to severe stroke group (score ≥8) according to the National Institutes of Health Stroke Scale.The general clinical data,laboratory measurements,and PLR were compared.Multivariate logistic regression analysis was used to identify the independent risk factors for LAA and its severity.Results A total of 676 patients with acute ischemic stroke were enrolled,including 391 patients with LAA,224 of them with mild stroke and 167 with moderate to severe stroke;285 with non-LAA,including 94 cardiogenic embolism,137 small vessel occlusion,18 other undetermined etiology and 36 undetermined etiology.PLR in the LAA group was significantly higher than that in the non-LAA group (172.24 ± 70.45 vs.148.37 ± 45.84;t =5.001,P ＜ 0.001).Multivariate logistic regression analysis showed that PLR (odds ratio 1.012,95％ confidence interval 1.004-1.021;P =0.006) was an independent risk factor for LAA.PLR in the mild LAA group was significantly lower than that in the moderate to severe LAA group (149.74 ±47.68 vs.202.42 ± 83.70;t =7.864,P ＜0.001).Multivariate logistic regression analysis showed that PLR (odds ratio 1.025,95％ confidence interval 1.008-1.042;P =0.003) was an independent risk factor for the severity of LAA.Conclusions PLR is associated with LAA and its severity.