Significance of ultrasound tissue characteristics of carotid atherosclerotic plaques in predicting cardiocerebrovascular events in patients with type 2 diabetes / 国际脑血管病杂志

ABSTRACT

Objective To investigate the predictive value of ultrasonic tissue charateristics of carotid atherosclerotic plaques in cardiocerebrovascular events in patients with type 2 diabetes mellitus (T2DM).Methods From January 2003 to December 2015,patients with T2DM treated in Xi'an Gaoxin Hospital were selected.Their carotid atherosclerotic plaques were examined by ultrasound.Intergrated backscatter (IBS) and thickness of carotid plaques of the patients were documented.The cardiocerebrovascular events were folbwed up prospectively.Kaplan-Meier curve,COX proportional risk regression model,and receiver operating characteristic (ROC) curve were used to compare and analyze the predictive values of calibratedIBS (C-IBS),Framingham Risk Score (FRS) and plaque thickness for the risk of cardiocerebrovascular events in patients with T2DM.Results There was significant difference in the risk of cardiovascular events between the low C-IBS group (n=48,C-IBS ＜17.1 dB) and the high C-IBS group (n=48,C-IBS ≥17.1 dB) (35.4％ vs.12.5％;P=0.015).There was no significant difference in the risk of cardiocerebrovascular events between the thin plaque group (n =48,plaque thickness ＜ 1.3 mm) and the thick plaque group (n=48,plaque thickness ＞1.3 mm) (14.6％ vs.33.3％;P=0.070).COX proportional risk regression model analysis showed that C-IBS (hazard ratio,1.505,95％ confidence interval 1.196-1.893,P=0.001) and plaque thickness (hazard ratio,4.794,95％ confidence interval 1.142-20.130,P =0.032) were the independent risk factors for the risk of cardiocerebrovascular events.ROC curve analysis found that the combination of C-IBS,FRS and plaque thickness could predict the risk of cardiocerebrovascular events in patients with T2DM.Conclusion Ultrasonic tissue characteristics of carotid atherosclerotic plaque (C-IBS and plaque thickness) in combination with FRS may predict cardiocerebrovascular events in patients with T2DM.